Research and Development Publications

The Griffin Institute/NPIMR Publications

  1. Olayanju, A., L. Jones, K. Greco, C. E. Goldring, and T. Ansari. “Application of Porcine Gastrointestinal Organoid Units as a Potential in Vitro Tool for Drug Discovery and Development.” J Appl Toxicol 39, no. 1 (01 2019): 4-15. https://dx.doi.org/10.1002/jat.3641
  2. Bage, T., T. Edymann, A. D. Metcalfe, B. Dheansa, and L. Mbundi. “Ex Vivo Culture of Keratinocytes on Papillary and Reticular Dermal Layers Remodels Skin Explants Differently: Towards Improved Wound Care.” Arch Dermatol Res 311, no. 8 (Oct 2019): 647-52. https://dx.doi.org/10.1007/s00403-019-01941-w.
  3. Greco, K. V., L. G. Jones, I. Obiri-Yeboa, and T. Ansari. “Creation of an Acellular Vaginal Matrix for Potential Vaginal Augmentation and Cloacal Repair.” J Pediatr Adolesc Gynecol 31, no. 5 (Oct 2018): 473-79. https://dx.doi.org/10.1016/j.jpag.2018.05.003.
  4. Francis, L., K. V. Greco, A. R. Boccaccini, J. J. Roether, N. R. English, H. Huang, R. Ploeg, and T. Ansari. “Development of a Novel Hybrid Bioactive Hydrogel for Future Clinical Applications.” J Biomater Appl 33, no. 3 (09 2018): 447-65. https://dx.doi.org/10.1177/0885328218794163.
  5. Greco, K. V., L. Francis, H. Huang, R. Ploeg, A. R. Boccaccini, and T. Ansari. “Is Quercetin an Alternative Natural Crosslinking Agent to Genipin for Long-Term Dermal Scaffolds Implantation?”, J Tissue Eng Regen Med 12, no. 3 (03 2018): e1716-e24. https://dx.doi.org/10.1002/term.2338.
  6. Vas, W. J., M. Shah, T. S. Blacker, M. R. Duchen, P. Sibbons, and S. J. Roberts. “Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic.” Tissue Eng Part A 24, no. 17-18 (09 2018): 1364-76. https://dx.doi.org/10.1089/ten.TEA.2017.0450.
  7. Wang, F., Y. Maeda, V. Zachar, T. Ansari, and J. Emmersen. “Regeneration of the Oesophageal Muscle Layer from Oesophagus Acellular Matrix Scaffold Using Adipose-Derived Stem Cells.” Biochem Biophys Res Commun 503, no. 1 (09 2018): 271-77. https://dx.doi.org/10.1016/j.bbrc.2018.06.014.
  8. Ansari, T., P. Lange, A. Southgate, K. Greco, C. Carvalho, L. Partington, A. Bullock, S. MacNeil, M. W. Lowdell, P. D. Sibbons, and M. A. Birchall. “Stem Cell-Based Tissue-Engineered Laryngeal Replacement.” Stem Cells Transl Med 6, no. 2 (02 2017): 677-87. https://dx.doi.org/10.5966/sctm.2016-0130.
  9. Elliott, M. J., C. R. Butler, A. Varanou-Jenkins, L. Partington, C. Carvalho, E. Samuel, C. Crowley, P. Lange, N. J. Hamilton, R. E. Hynds, T. Ansari, P. Sibbons, A. Fierens, C. McLaren, D. Roebuck, C. Wallis, N. Muthialu, R. Hewitt, D. Crabbe, S. M. Janes, P. De Coppi, M. W. Lowdell, and M. A. Birchall. “Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a Gmp-Compliant Tissue-Engineered Medicine.” Stem Cells Transl Med 6, no. 6 (06 2017): 1458-64. https://dx.doi.org/10.1002/sctm.16-0443.
  10. Kaneva, M. K., K. V. Greco, S. E. Headland, T. Montero-Melendez, P. Mori, K. Greenslade, C. Pitzalis, A. Moore, and M. Perretti. “Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates.” J Immunol 198, no. 7 (04 2017): 2876-85. https://dx.doi.org/10.4049/jimmunol.1601111.
  11. Herrmann, P., T. Ansari, A. Southgate, A. Varanou Jenkins, L. Partington, C. Carvalho, S. Janes, M. Lowdell, P. D. Sibbons, and M. A. Birchall. “In Vivo Implantation of a Tissue Engineered Stem Cell Seeded Hemi-Laryngeal Replacement Maintains Airway, Phonation, and Swallowing in Pigs.” J Tissue Eng Regen Med (Oct 2017). https://dx.doi.org/10.1002/term.2596.
  12. Lange, P., K. Greco, L. Partington, C. Carvalho, S. Oliani, M. A. Birchall, P. D. Sibbons, M. W. Lowdell, and T. Ansari. “Pilot Study of a Novel Vacuum-Assisted Method for Decellularization of Tracheae for Clinical Tissue Engineering Applications.” J Tissue Eng Regen Med 11, no. 3 (03 2017): 800-11. https://dx.doi.org/10.1002/term.1979.
  13. Lange, P., H. Shah, M. Birchall, P. Sibbons, and T. Ansari. “Characterization of a Biologically Derived Rabbit Tracheal Scaffold.” J Biomed Mater Res B Appl Biomater 105, no. 7 (10 2017): 2126-35. https://dx.doi.org/10.1002/jbm.b.33741.
  14. Maughan, E. F., C. R. Butler, C. Crowley, G. Z. Teoh, M. den Hondt, N. J. Hamilton, R. E. Hynds, P. Lange, T. Ansari, L. Urbani, S. M. Janes, P. de Coppi, M. A. Birchall, and M. J. Elliott. “A Comparison of Tracheal Scaffold Strategies for Pediatric Transplantation in a Rabbit Model.” Laryngoscope 127, no. 12 (12 2017): E449-E57. https://dx.doi.org/10.1002/lary.26611.
  15. Oke, S., M. N. Walter, T. Ansari, and S. M. Gabe. “Growth Factors and Their Use in Short Bowel.” Curr Opin Gastroenterol 33, no. 3 (May 2017): 212-17. https://dx.doi.org/10.1097/MOG.0000000000000351.
  16. Eldridge, S., G. Nalesso, H. Ismail, K. Vicente-Greco, P. Kabouridis, M. Ramachandran, A. Niemeier, J. Herz, C. Pitzalis, M. Perretti, and F. Dell’Accio. “Agrin Mediates Chondrocyte Homeostasis and Requires Both Lrp4 and Α-Dystroglycan to Enhance Cartilage Formation in Vitro and in Vivo.” Ann Rheum Dis 75, no. 6 (06 2016): 1228-35. https://dx.doi.org/10.1136/annrheumdis-2015-207316.
  17. Mimura, K. K., A. R. Moraes, A. C. Miranda, R. Greco, T. Ansari, P. Sibbons, K. V. Greco, and S. M. Oliani. “Mechanisms Underlying Heterologous Skin Scaffold-Mediated Tissue Remodeling.” Sci Rep 6 (10 2016): 35074. https://dx.doi.org/10.1038/srep35074.
  18. Nowocin, A. K., A. Southgate, S. M. Gabe, and T. Ansari. “Biocompatibility and Potential of Decellularized Porcine Small Intestine to Support Cellular Attachment and Growth.” J Tissue Eng Regen Med 10, no. 1 (Jan 2016): E23-33. https://dx.doi.org/10.1002/term.1750.
  19. Nowocin, A. K., A. Southgate, S. Shurey, P. Sibbons, S. M. Gabe, and T. Ansari. “The Development and Implantation of a Biologically Derived Allograft Scaffold.” J Tissue Eng Regen Med 10, no. 2 (Feb 2016): 140-8. https://dx.doi.org/10.1002/term.1722.
  20. Teixeira, R. A., K. K. Mimura, L. P. Araujo, K. V. Greco, and S. M. Oliani. “The Essential Role of Annexin A1 Mimetic Peptide in the Skin Allograft Survival.” J Tissue Eng Regen Med 10, no. 2 (Feb 2016): E44-53. https://dx.doi.org/10.1002/term.1773.
  21. Tsiamoulos, Z. P., P. Sibbons, S. Morris, C. P. Hancock, and B. P. Saunders. “A Novel Multimodality Endoscopic Device for Colonic Submucosal Dissection Using a Combination of Bipolar Radiofrequency and Microwave Modalities.” Endoscopy 48, no. 3 (Mar 2016): 271-6. https://dx.doi.org/10.1055/s-0042-101344.
  22. Greco, K. V., L. Francis, M. Somasundaram, G. Greco, N. R. English, J. A. Roether, A. R. Boccaccini, P. Sibbons, and T. Ansari. “Characterisation of Porcine Dermis Scaffolds Decellularised Using a Novel Non-Enzymatic Method for Biomedical Applications.” J Biomater Appl 30, no. 2 (Aug 2015): 239-53. https://dx.doi.org/10.1177/0885328215578638.
  23. Sahdev, R., T. I. Ansari, S. M. Higham, and S. P. Valappil. “Potential Use of Gallium-Doped Phosphate-Based Glass Material for Periodontitis Treatment.” J Biomater Appl 30, no. 1 (Jul 2015): 85-92. https://dx.doi.org/10.1177/0885328215571952.
  24. Greco, K. V., G. Nalesso, M. K. Kaneva, J. Sherwood, A. J. Iqbal, N. Moradi-Bidhendi, F. Dell’Accio, and M. Perretti. “Analyses on the Mechanisms That Underlie the Chondroprotective Properties of Calcitonin.” Biochem Pharmacol 91, no. 3 (Oct 2014): 348-58. https://dx.doi.org/10.1016/j.bcp.2014.07.034.
  25. Brigic, A., A. Southgate, P. Sibbons, S. K. Clark, C. Fraser, and R. H. Kennedy. “Full-Thickness Laparoendoscopic Colonic Excision in an Experimental Model.” Br J Surg 100, no. 12 (Nov 2013): 1649-54. https://dx.doi.org/10.1002/bjs.9298.
  26. Brigic, A., A. Southgate, P. D. Sibbons, S. K. Clark, C. Fraser, and R. H. Kennedy. “Full-Thickness Laparoendoscopic Stapled Excision of Colonic Lesion in a Porcine Ex Vivo Model.” Endoscopy 45 Suppl 2 UCTN (2013): E167-8. https://dx.doi.org/10.1055/s-0032-1326462.
  27. Fishman, J. M., M. W. Lowdell, L. Urbani, T. Ansari, A. J. Burns, M. Turmaine, J. North, P. Sibbons, A. M. Seifalian, K. J. Wood, M. A. Birchall, and P. De Coppi. “Immunomodulatory Effect of a Decellularized Skeletal Muscle Scaffold in a Discordant Xenotransplantation Model.” Proc Natl Acad Sci U S A 110, no. 35 (Aug 2013): 14360-5. https://dx.doi.org/10.1073/pnas.1213228110.
  28. Gerhardt, L. C., K. L. Widdows, M. M. Erol, A. Nandakumar, I. S. Roqan, T. Ansari, and A. R. Boccaccini. “Neocellularization and Neovascularization of Nanosized Bioactive Glass-Coated Decellularized Trabecular Bone Scaffolds.” J Biomed Mater Res A 101, no. 3 (Mar 2013): 827-41. https://dx.doi.org/10.1002/jbm.a.34373.
  29. Luiz Zanoni, F., J. W. Costa Cruz, J. O. Martins, S. Benabou, K. Vicente Greco, A. C. Ramos Moreno, M. Baquerizo Martinez, F. Ferraro Calderaro, M. Rocha e Silva, and P. Sannomiya. “Hypertonic Saline Solution Reduces Mesenteric Microcirculatory Dysfunctions and Bacterial Translocation in a Rat Model of Strangulated Small Bowel Obstruction.” Shock 40, no. 1 (Jul 2013): 35-44. https://dx.doi.org/10.1097/SHK.0b013e318299d3fa.
  30. de Castro Brás, L. E., S. Shurey, and P. D. Sibbons. “Evaluation of Crosslinked and Non-Crosslinked Biologic Prostheses for Abdominal Hernia Repair.” Hernia 16, no. 1 (Feb 2012): 77-89. https://dx.doi.org/10.1007/s10029-011-0859-0.
  31. Fishman, J. M., T. Ansari, P. Sibbons, P. De Coppi, and M. A. Birchall. “Decellularized Rabbit Cricoarytenoid Dorsalis Muscle for Laryngeal Regeneration.” Ann Otol Rhinol Laryngol 121, no. 2 (Feb 2012): 129-38. https://dx.doi.org/10.1177/000348941212100210.
  32. Gerhardt, L. C., J. Schmidt, J. A. Sanz-Herrera, F. P. Baaijens, T. Ansari, G. W. Peters, and C. W. Oomens. “A Novel Method for Visualising and Quantifying through-Plane Skin Layer Deformations.” J Mech Behav Biomed Mater 14 (Oct 2012): 199-207. https://dx.doi.org/10.1016/j.jmbbm.2012.05.014.
  33. Hart, A. J., P. D. Quinn, F. Lali, B. Sampson, J. A. Skinner, J. J. Powell, J. Nolan, K. Tucker, S. Donell, A. Flanagan, and J. F. Mosselmans. “Cobalt from Metal-on-Metal Hip Replacements May Be the Clinically Relevant Active Agent Responsible for Periprosthetic Tissue Reactions.” Acta Biomater 8, no. 10 (Oct 2012): 3865-73. https://dx.doi.org/10.1016/j.actbio.2012.05.003.
  34. Kennedy, R. H., R. A. Cahill, A. Brigic, P. Sibbons, and C. Fraser. “Full-Thickness Laparoendoscopic Excision in the Stomach: The Flex Technique.” Surg Innov 19, no. 1 (Mar 2012): 93-8. https://dx.doi.org/10.1177/1553350611415871.
  35. Lu, F., M. Royle, F. V. Lali, A. J. Hart, S. Collins, J. Housden, and J. C. Shelton. “Simple Isolation Method for the Bulk Isolation of Wear Particles from Metal on Metal Bearing Surfaces Generated in a Hip Simulator Test.” J Mater Sci Mater Med 23, no. 4 (Apr 2012): 891-901. https://dx.doi.org/10.1007/s10856-012-4573-y.
  36. Totonelli, G., P. Maghsoudlou, J. M. Fishman, G. Orlando, T. Ansari, P. Sibbons, M. A. Birchall, A. Pierro, S. Eaton, and P. De Coppi. “Esophageal Tissue Engineering: A New Approach for Esophageal Replacement.” World J Gastroenterol 18, no. 47 (Dec 2012): 6900-7. https://dx.doi.org/10.3748/wjg.v18.i47.6900.
  37. Widdows, K., A. O’Malley, B. O’Neill, J. Kingdom, J. Gillan, and T. Ansari. “Altered Placental Development in Pregnancies Resulting in Sudden Infant Death Syndrome (Sids).” Early Hum Dev 88, no. 10 (Oct 2012): 805-11. https://dx.doi.org/10.1016/j.earlhumdev.2012.05.006.
  38. Davda, K., F. V. Lali, B. Sampson, J. A. Skinner, and A. J. Hart. “An Analysis of Metal Ion Levels in the Joint Fluid of Symptomatic Patients with Metal-on-Metal Hip Replacements.” J Bone Joint Surg Br 93, no. 6 (Jun 2011): 738-45. https://dx.doi.org/10.1302/0301-620X.93B6.25804.
  39. Di Petta, A., K. V. Greco, E. O. Castro, F. D. Lopes, M. A. Martins, V. L. Capelozzi, L. F. Moreira, and P. Sannomiya. “Insulin Modulates Inflammatory and Repair Responses to Elastase-Induced Emphysema in Diabetic Rats.” Int J Exp Pathol 92, no. 6 (Dec 2011): 392-9. https://dx.doi.org/10.1111/j.1365-2613.2011.00787.x.
  40. Greco, K. V., A. J. Iqbal, L. Rattazzi, G. Nalesso, N. Moradi-Bidhendi, A. R. Moore, M. B. Goldring, F. Dell’Accio, and M. Perretti. “High Density Micromass Cultures of a Human Chondrocyte Cell Line: A Reliable Assay System to Reveal the Modulatory Functions of Pharmacological Agents.” Biochem Pharmacol 82, no. 12 (Dec 2011): 1919-29. https://dx.doi.org/10.1016/j.bcp.2011.09.009.
  41. Iqbal, A. J., A. L. Sampaio, F. Maione, K. V. Greco, T. Niki, M. Hirashima, M. Perretti, and D. Cooper. “Endogenous Galectin-1 and Acute Inflammation: Emerging Notion of a Galectin-9 Pro-Resolving Effect.” Am J Pathol 178, no. 3 (Mar 2011): 1201-9. https://dx.doi.org/10.1016/j.ajpath.2010.11.073.
  42. Patel, H. B., T. Montero-Melendez, K. V. Greco, and M. Perretti. “Melanocortin Receptors as Novel Effectors of Macrophage Responses in Inflammation.” Front Immunol 2 (2011): 41. https://dx.doi.org/10.3389/fimmu.2011.00041.
  43. Zanoni, F. L., S. Benabou, K. V. Greco, A. C. Moreno, J. W. Cruz, F. P. Filgueira, M. B. Martinez, L. F. Figueiredo, M. R. Silva, and P. Sannomiya. “Mesenteric Microcirculatory Dysfunctions and Translocation of Indigenous Bacteria in a Rat Model of Strangulated Small Bowel Obstruction.” Clinics (Sao Paulo) 64, no. 9 (2009): 911-9. https://dx.doi.org/10.1590/S1807-59322009000900013.
  44. Simmonds, R. E., F. V. Lali, T. Smallie, P. L. Small, and B. M. Foxwell. “Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism.” J Immunol 182, no. 4 (Feb 2009): 2194-202. https://dx.doi.org/10.4049/jimmunol.0802294.
  45. Zambelli, V. O., S. C. Sampaio, L. S. Sudo-Hayashi, K. Greco, L. R. Britto, A. S. Alves, B. C. Zychar, L. R. Gonçalves, D. D. Spadacci-Morena, R. Otton, M. S. Della-Casa, R. Curi, and Y. Cury. “Crotoxin Alters Lymphocyte Distribution in Rats: Involvement of Adhesion Molecules and Lipoxygenase-Derived Mediators.” Toxicon 51, no. 8 (Jun 2008): 1357-67. https://dx.doi.org/10.1016/j.toxicon.2008.03.004.
  46. Nicolini, P., J. W. Nascimento, K. V. Greco, and F. G. de Menezes. “[Factors Related to Prescriptions of Antibiotics in a Public Pharmacy in the Western Region of the City of São Paulo].” Cien Saude Colet 13 Suppl (Apr 2008): 689-96. https://dx.doi.org/10.1590/s1413-81232008000700018.
  47. Greco, K. V., P. F. Lara, R. M. Oliveira-Filho, R. V. Greco, and L. S. Sudo-Hayashi. “Lymphatic Regeneration across an Incisional Wound: Inhibition by Dexamethasone and Aspirin, and Acceleration by a Micronized Purified Flavonoid Fraction.” Eur J Pharmacol 551, no. 1-3 (Dec 2006): 131-42. https://dx.doi.org/10.1016/j.ejphar.2006.08.090.
  48. Moriguchi, P., P. Sannomiya, P. F. Lara, R. M. Oliveira-Filho, K. V. Greco, and L. S. Sudo-Hayashi. “Lymphatic System Changes in Diabetes Mellitus: Role of Insulin and Hyperglycemia.” Diabetes Metab Res Rev 21, no. 2 (2005 Mar-Apr 2005): 150-7. https://dx.doi.org/10.1002/dmrr.500.
  49. Lali, F. V., J. Crawley, D. A. McCulloch, and B. M. Foxwell. “A Late, Prolonged Activation of the Phosphatidylinositol 3-Kinase Pathway Is Required for T Cell Proliferation.” J Immunol 172, no. 6 (Mar 2004): 3527-34. https://dx.doi.org/10.4049/jimmunol.172.6.3527.
  50. Hunt, A. E., L. M. Williams, F. V. Lali, and B. M. Foxwell. “Il-4 Regulation of P38 Mapk Signalling Is Dependent on Cell Type.” Cytokine 18, no. 6 (Jun 2002): 295-303. https://dx.doi.org/10.1006/cyto.2002.1043.
  51. Lali, F. V., A. E. Hunt, S. J. Turner, and B. M. Foxwell. “The Pyridinyl Imidazole Inhibitor Sb203580 Blocks Phosphoinositide-Dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-Stimulated T Cells Independently of P38 Mitogen-Activated Protein Kinase.” J Biol Chem 275, no. 10 (Mar 2000): 7395-402. https://dx.doi.org/10.1074/jbc.275.10.7395.
  52. Hunt, A. E., F. V. Lali, J. D. Lord, B. H. Nelson, T. Miyazaki, K. J. Tracey, and B. M. Foxwell. “Role of Interleukin (Il)-2 Receptor Beta-Chain Subdomains and Shc in P38 Mitogen-Activated Protein (Map) Kinase and P54 Map Kinase (Stress-Activated Protein Kinase/C-Jun N-Terminal Kinase) Activation. Il-2-Driven Proliferation Is Independent of P38 and P54 Map Kinase Activation.” J Biol Chem 274, no. 11 (Mar 1999): 7591-7. https://dx.doi.org/10.1074/jbc.274.11.7591.
  53. Crawley, J. B., L. Rawlinson, F. V. Lali, T. H. Page, J. Saklatvala, and B. M. Foxwell. “T Cell Proliferation in Response to Interleukins 2 and 7 Requires P38map Kinase Activation.” J Biol Chem 272, no. 23 (Jun 1997): 15023-7. https://dx.doi.org/10.1074/jbc.272.23.15023
  54. Page, T. H., F. V. Lali, N. Groome, and B. M. Foxwell. “Association of the Common Gamma-Chain with the Human Il-7 Receptor Is Modulated by T Cell Activation.” J Immunol 158, no. 12 (Jun 1997): 5727-35.
  55. Page, T. H., F. V. Lali, and B. M. Foxwell. “Interleukin-7 Activates P56lck and P59fyn, Two Tyrosine Kinases Associated with the P90 Interleukin-7 Receptor in Primary Human T Cells.” Eur J Immunol 25, no. 10 (Oct 1995): 2956-60. https://dx.doi.org/10.1002/eji.1830251036.