Preclinical Research Services
Our scientific and research team provides high quality studies to propel research, through the most appropriate models, into the marketplace. We provide a full, comprehensive and bespoke service tailored to specific requirements. Our team of dedicated staff have many years of experience and are happy to discuss and advise the correct model/surgical technique for research initiatives. We provide a full, comprehensive service tailored to your requirements with surgical facilities and laboratories certified by MHRA as a Good Laboratory Practice (GLP) facility, in accordance with Directive 2004/9/EC. We offer a wide range of Research models, both in vitro and in vivo, and we also hold a Human Tissue Authority (HTA) research license.
For further information about our preclinical research services please contact Professor Hua at j.hua@griffininstitute.org.uk
Preclinical Research Services
Our Models and Services
Our current range of in-vitro models includes
• Tissue specific organoids for drug screening• Decellularised liver, colon, small bowel and skin
• Keratinocyte: Fibroblast co-culture
Our laboratory services include
• Histology (paraffin, resin)• Immunocytochemistry (ICC)
• Enzyme-linked immunosorbent assay (ELISA)
• qRT-PCR
• Proliferation assay
• Immuno-blotting
• DNA/RNA extraction, quantification and gel electrophoresis
• Collagen and GAG quantification
• 2D and 3D in-vitro cell culture for material cytotoxicity
• Freeze drying biomaterials and tissue sections
• Chorioallantoic Membrane (CAM) Assay
Our Achievements
We have a wealth of experience and in the last 5 years to date we have:-• Undertaken 142 research studies (GLP & non GLP)
• Held 10 project licences
• Held 86 personal licences (surgical & nonsurgical)
We have an experienced team of researchers and 5 members of surgical staff who possess Home Office Licences / competencies (not including anaesthetists, technicians, and other surgical staff)
Preclinical Services and Surgical Research
Orthopaedic
• Prosthesis implantation
• Biomaterial testing and assessment
In vivo microbiological studies
Material biocompatibility
• Implantation of devices and materials for biocompatibility testing
Wound healing
• Improving wound healing/epithelialization
• Reducing scarring
• Reducing infection
Implantation of biologically derived tissue scaffolds
• Tissue/organ implantation
Prevention of post-surgical adhesions
• Induction, assessment and treatment of adhesions
• Use of devices to prevent, diagnose and treat post-surgical adhesions
• Evaluation of haemostatic materials or devices
Bowel anastomosis and drug delivery
• Evaluation of novel technologies to treat conditions related to gastrointestinal surgery, bowel anastomosis and chemotherapy delivery
Haemostasis
• Testing of haemostatic devices or materials
Testing endoscopic, laparoscopic and robotic devices
• Evaluation of device for manoeuvrability, locomotion, support functions (e.g., flush, suction, insufflation) and/or creation and treatment of defects
Ischaemia prevention
• Treatment of aneurysms
• Testing indwelling pacing and sensing devices
• Monitoring perfusion and testing devices to monitor perfusion
Ocular injury and treatment and delivery of substances
• Evaluation of efficacy and/or safety of substances intended for delivery to the eye
• Treatment and monitoring of diabetes
• Induction of diabetes
• Testing endoscopic cryoablation devices
• Adjusting and measuring blood glucose levels
Rat brief access taste aversion (BATA) test
• In vivo assessment of taste-aversiveness of pharmaceutical compounds and formulations
Neurovascular surgery
Endovascular surgery
Vascular microsurgery
Sciatic nerve regeneration
